新規なチエノ-ピリジンおよびチエノ-ピリミジン誘導体およびMGLUR2-受容体のポジティブアロステリックモジュレーターとしてのそれらの使用

Japanese Patent JP2008513413

A

The present invention relates to novel compounds, in particular novel thieno-pyridine and thieno-pyrimidine derivatives according to Formula (I), wherein all radicals are defined in the application. The compounds according to the invention are positive allosteric modulators of metabotropic receptors-subtype 2 ("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

Imogai Hassan Julian
Duvey Giraum Albert Jacques
Sid Nues Jose Maria
Rutgens Robert Johans
Le Paul Emmanuel Christian

JP2007531758A

May 01, 2008

September 16, 2005

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Jansen Pharmaceuticals NV
ADEX Pharma SA

C07D495/04; A61K31/519; A61K49/00; A61P25/06; A61P25/08; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P25/34; A61P25/36; A61P43/00

JP2004509059A	2004-03-25
JP2000516223A	2000-12-05
JPS5268197A	1977-06-06
JP2001525325A	2001-12-11
JP2002308882A	2002-10-23
JPH0311067A	1991-01-18
JPH10298180A	1998-11-10
JP2007533611A	2007-11-22
JP2008509714A	2008-04-03

WO2004092123A2	2004-10-28
WO2001056990A2	2001-08-09
WO2004092135A2	2004-10-28
EP0452002A2	1991-10-16
DD245667A1	1987-05-13
WO2001032632A2	2001-05-10

Shunichiro Suzuki
Koji Makimura
Yoshiko Yamoto

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