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Title:
CB1拮抗薬としてのジアリール尿素
Document Type and Number:
Japanese Patent JP2008518014
Kind Code:
A
Abstract:
Compounds of Formula I are provided. In which the variables are as described herein. Such compounds may be used to modulate CB1 activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to CB1 modulation in humans, domesticated companion animals and livestock animals, including appetite disorders, obesity and addictive disorders. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies and various in vitro assays.

Inventors:
ハチソン、 アラン ジェイ.
ユアン、 ジュン
Application Number:
JP2007539032A
Publication Date:
May 29, 2008
Filing Date:
October 24, 2005
Export Citation:
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Assignee:
NEUROGEN CORPORATION
International Classes:
A61K31/17; A61K31/343; A61K31/357; A61K31/40; A61K31/4045; A61K31/41; A61K31/415; A61K31/4164; A61K31/42; A61K31/426; A61K31/428; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4453; A61K31/47; A61K31/4965; A61K31/505; A61K31/5377; A61P1/00; A61P1/16; A61P3/04; A61P11/06; A61P19/08; A61P25/18; A61P25/24; A61P25/28; A61P25/32; A61P25/34; A61P31/04; C07C275/34; C07C275/38; C07C275/40; C07C275/42; C07C311/05; C07D209/08; C07D213/64; C07D213/75; C07D213/76; C07D215/12; C07D215/38; C07D231/40; C07D233/61; C07D239/26; C07D241/12; C07D261/08; C07D277/28; C07D277/82; C07D295/12; C07D307/83; C07D319/18; C07D403/12
Attorney, Agent or Firm:
伊藤 克博
小野 暁子