Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
置換された四環式テトラヒドロフラン、ピロリジンおよびテトラヒドロチオフェン誘導体
Document Type and Number:
Japanese Patent JP2008523032
Kind Code:
A
Abstract:
This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.

Inventors:
シド-ヌニエス,ホセ・マリア
メゲンス,アントニウス・アドリアヌス・ヘンドリクス・ペトルス
トラバンコ-スアレス,アンドレス・アベリノ
クークニ,モハメド
ホールネルト,ジヨルジエ・ジヨセフ・コルネリス
コンペルノル,フラン・ジヨセフ・コルネリウス
コズレキ,トマス
マオ,フア
ジヤ,スシル・チヤンドラ
フエルナンデス-ガデア,フランシスコ・ザビエル
Application Number:
JP2007544905A
Publication Date:
July 03, 2008
Filing Date:
December 06, 2005
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D209/94; A61K31/343; A61K31/352; A61K31/381; A61K31/403; A61K31/407; A61K31/4188; A61K31/435; A61K31/496; A61K31/4985; A61K31/5377; A61P1/04; A61P3/04; A61P7/02; A61P9/00; A61P9/12; A61P15/00; A61P25/00; A61P25/06; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P43/00; C07D221/18; C07D307/93; C07D311/94; C07D333/80; C07D487/04; C07D491/044
Domestic Patent References:
JP2008503544A2008-02-07
JP2003533528A2003-11-11
Foreign References:
WO1999019317A11999-04-22
WO1997038991A11997-10-23
Attorney, Agent or Firm:
特許業務法人小田島特許事務所
小田島 平吉