Title:
超音波媒介デリバリー用ガス充填マイクロカプセル含有医薬組成物
Document Type and Number:
Japanese Patent JP2008538367
Kind Code:
A
Abstract:
Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein.
Inventors:
Thierry Betanger
Feng Yang
Sophie Mayer-Umbert
Peter Flinking
Feng Yang
Sophie Mayer-Umbert
Peter Flinking
Application Number:
JP2008507051A
Publication Date:
October 23, 2008
Filing Date:
April 11, 2006
Export Citation:
Assignee:
BRACCO RESEARCH S.A.
International Classes:
A61K9/50; A61J3/07; A61K47/06; A61K47/14; A61K47/32; A61K47/48; A61B8/00; A61K31/7088
Foreign References:
| US20040258760A1 | 2004-12-23 | |||
| WO2004060425A2 | 2004-07-22 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Minato Saito
Nagatoshi Shinagawa
Samejima Mutsumi
Minato Saito
Nagatoshi Shinagawa