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Patent Searching and Data


Title:
シュードモナス外毒素ACD4+T細胞エピトープ
Document Type and Number:
Japanese Patent JP2009511000
Kind Code:
A
Abstract:
The present invention provides PE CD4+T-cell epitopes, as well as novel variants that exhibit reduced immunogenic responses, as compared to the parental PE. The present invention further provides DNA molecules that encode novel PE variants, host cells comprising DNA encoding novel PE variants, as well as methods for making PEs less immunogenic. In addition, the present invention provides various compositions that comprise these PE variants that are less immunogenic than wild-type PEs.

Inventors:
ハーディング,フィオナ アン
Application Number:
JP2008530608A
Publication Date:
March 19, 2009
Filing Date:
September 12, 2006
Export Citation:
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Assignee:
メディミューン リミテッド
International Classes:
C12N15/09; A61K39/395; A61P35/00; C07K7/08; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Foreign References:
WO2005052006A22005-06-09
WO1999053038A21999-10-21
Other References:
JPN6011069597; JOURNAL OF BIOLOGICAL CHEMISTRY Vol.269, No.10, 1994, 7610-7616
JPN6011069598; EUROPEAN JOURNAL OF IMMUNOLOGY Vol.27, No.6, 1997, 1459-1468
Attorney, Agent or Firm:
平木 祐輔
石井 貞次
藤田 節
新井 栄一