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Patent Searching and Data


Title:
選択的グリコシダーゼ阻害剤およびその使用
Document Type and Number:
Japanese Patent JP2010501598
Kind Code:
A
Abstract:
The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.

Inventors:
デイビッド・ボカドロ
アーネスト・マクイーチャーン
ガレット・ホイットワース
マシュー・マコーレー
ジュリア・ヘイノネン
キース・スタッブス
トン-シュアン・リ
Application Number:
JP2009525881A
Publication Date:
January 21, 2010
Filing Date:
August 31, 2007
Export Citation:
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Assignee:
Simon Fraser University
International Classes:
C07H9/06; A61K31/7042; A61P1/04; A61P5/14; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/04; A61P17/06; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07H13/06; C12Q1/25; C12N9/24
Foreign References:
Other References:
JPN6013011097; Carbohydrate Research vol.154, 1986, pp.49-62
JPN6013011100; Tetrahedron 50(10), 1994, pp.3273-3296
JPN6013011101; Anales Quimica Serie C 84(1), 1988, pp.5-11
JPN6013011094; SYNLETT Special Issue, 1997, pp.435-436
JPN6013011095; The Journal of Biological Chemistry 280(27), 2005, pp.25313-25322
JPN6013011097; Carbohydrate Research vol.154, 1986, pp.49-62
JPN6013011100; Tetrahedron 50(10), 1994, pp.3273-3296
JPN6013011101; Anales Quimica Serie C 84(1), 1988, pp.5-11
Attorney, Agent or Firm:
田中 光雄
山崎 宏
松谷 道子
志賀 美苗
櫻井 陽子
橋本 諭志