選択的グリコシダーゼ阻害剤およびその使用

Title:

選択的グリコシダーゼ阻害剤およびその使用

Document Type and Number:

Japanese Patent JP2010501598

Kind Code:

A

Abstract:

The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.

Inventors:

David Bocador
Ernest McEchern
Garrett Whitworth
Matthew Macaulay
Julia Heinonen
Keith Stubbs
Ton-Suan Li

Application Number:

JP2009525881A

Publication Date:

January 21, 2010

Filing Date:

August 31, 2007

Export Citation:

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Assignee:

Simon Fraser University

International Classes:

C07H9/06; A61K31/7042; A61P1/04; A61P5/14; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/04; A61P17/06; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07H13/06; C12Q1/25; C12N9/24

Other References:

JPN6013011097; Ｃａｒｂｏｈｙｄｒａｔｅ　Ｒｅｓｅａｒｃｈｖｏｌ．１５４, 1986, ｐｐ．４９-６２
JPN6013011100; Ｔｅｔｒａｈｅｄｒｏｎ５０（１０）, 1994, ｐｐ．３２７３-３２９６
JPN6013011101; Ａｎａｌｅｓ　Ｑｕｉｍｉｃａ　Ｓｅｒｉｅ　Ｃ８４（１）, 1988, ｐｐ．５-１１
JPN6013011094; ＳＹＮＬＥＴＴＳｐｅｃｉａｌ　Ｉｓｓｕｅ, 1997, ｐｐ．４３５-４３６
JPN6013011095; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　Ｃｈｅｍｉｓｔｒｙ２８０（２７）, 2005, ｐｐ．２５３１３-２５３２２
JPN6013011097; Ｃａｒｂｏｈｙｄｒａｔｅ　Ｒｅｓｅａｒｃｈｖｏｌ．１５４, 1986, ｐｐ．４９-６２
JPN6013011100; Ｔｅｔｒａｈｅｄｒｏｎ５０（１０）, 1994, ｐｐ．３２７３-３２９６
JPN6013011101; Ａｎａｌｅｓ　Ｑｕｉｍｉｃａ　Ｓｅｒｉｅ　Ｃ８４（１）, 1988, ｐｐ．５-１１

Attorney, Agent or Firm:

Mitsuo Tanaka
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Sakurai Yoko
Satoshi Hashimoto

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