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Title:
難溶性薬物用の医薬組成物
Document Type and Number:
Japanese Patent JP2010526848
Kind Code:
A
Abstract:
The invention relates to solid dispersions of poorly soluble compounds formed by co-precipitation and hot melt extrusion, resulting in improved stability and bioavailability. The invention also relates to hot melt extrusion processes used to prepare such solid dispersions.

Inventors:
Chattage, Ashish
Don, Thornton
Sandoo, Harplate K
Shah, Nabnit Hargovindas
Application Number:
JP2010507877A
Publication Date:
August 05, 2010
Filing Date:
April 30, 2008
Export Citation:
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Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A61K9/10; A61K9/20; A61K9/48; A61K31/427; A61K47/32; A61K47/38; C07D417/12
Domestic Patent References:
JP2007504102A2007-03-01
JP2003518012A2003-06-03
JP2005320354A2005-11-17
JP2000229888A2000-08-22
JPH10505574A1998-06-02
JP2000095708A2000-04-04
JP2000514057A2000-10-24
Foreign References:
WO2006026500A12006-03-09
WO2006084696A12006-08-17
WO2007017249A12007-02-15
WO2005115330A22005-12-08
WO2006062980A22006-06-15
WO2007027494A22007-03-08
WO2006018188A22006-02-23
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito