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Patent Searching and Data

Document Type and Number:
Japanese Patent JP2011503084
Kind Code:
In its many embodiments, the present invention provides a novel class of pyrimidine analogs of formula (V) as targeted mechanism-based modulators of cell cycle checkpoints. Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint modulator of the invention. Also discussed are suitable combinations of the cell cycle checkpoint modulator with a checkpoint kinase inhibitor to produce synergistic apoptosis in cancer cells. The invention includes methods of treating cancers by administering the combination of the cell cycle checkpoint modulator and the checkpoint kinase inhibitor, pharmaceutical compositions comprising the activator as well as the combination and pharmaceutical kits.

Guji, Timothy Jay.
Parry, David A.
Labroli, Mark A.
Dwyer, Michael Pee.
Palouch, Kamil
Rosner, Kristen Yee.
Shen, Luiciao
Popovich-Muller, Janeta
Application Number:
Publication Date:
January 27, 2011
Filing Date:
November 05, 2008
Export Citation:
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Schering Corporation
International Classes:
C07H19/06; A61K31/4985; A61K31/519; A61K31/7068; A61P35/00; A61P43/00; C07H19/067
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita