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Title:
熱感応性組織癒着防止用組成物およびその製造方法
Document Type and Number:
Japanese Patent JP2012509129
Kind Code:
A
Abstract:
Provided is a thermosensitive composition preventing tissue adhesion and a method for preparing the same, and, more particularly, a thermosensitive composition preventing tissue adhesion which further contains a drug selectively inhibiting inflammatory response and a method for preparing the composition, in which the composition is produced through a chemical reaction by adding a cross-linking agent to an aqueous solution which contains a block copolymer containing a polyethyleneoxide block having the ability to suppress tissue adhesion, and a polymer with 10,000 to 1,000,000 g/mol of molecular weight which can be mixed with the copolymer; the composition is characterized in that the difference of viscosity, absorbance of visible rays region, and stability between the upper and lower liquid layers are within 10 % when centrifuging the composition; and also the method for preparing the composition enhances cross-linking homogenization and viscosity stability through simultaneous spraying and stirring methods without a reaction retardant.

Inventors:
Jin-Suk Choi
Yeon-Woo Lee
Yoon-Gee Lee
Jun-Hoo Kim
Jin-Ho Lee
Application Number:
JP2011537345A
Publication Date:
April 19, 2012
Filing Date:
September 17, 2009
Export Citation:
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Assignee:
Genewell Company Limited
Hannam University Institute Industry-Academia Corporation
International Classes:
A61L31/00
Domestic Patent References:
JP2003530136A2003-10-14
JP2000281794A2000-10-10
JP2005139293A2005-06-02
JPH10235230A1998-09-08
Foreign References:
KR100565881B12006-03-29
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro



 
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