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Title:
CGRP受容体アンタゴニスト
Document Type and Number:
Japanese Patent JP2013523733
Kind Code:
A
Abstract:
The disclosure generally relates to the compound of formula I, (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide, including pharmaceutically acceptable salts, which is a CGRP-receptor antagonist. The disclosure also relates to pharmaceutical compositions and methods for using the compound in the treatment of CGRP related disorders including migraine headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cancer.

Inventors:
プラサド・ブイ・チャトゥルベドゥラ
ジーン・エム・ドゥボーチック
ジョン・イー・マコー
Application Number:
JP2013502610A
Publication Date:
June 17, 2013
Filing Date:
March 11, 2011
Export Citation:
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Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D401/14; A61K31/496; A61P9/00; A61P11/00; A61P11/06; A61P15/00; A61P15/12; A61P17/02; A61P25/00; A61P25/04; A61P25/06; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
JP2005538959A2005-12-22
Foreign References:
Other References:
PAONE D V: "CALCITONIN GENE-RELATED PEPTIDE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE: A PATENT REVIEW", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. V19 N12, JPN5013006198, 1 December 2009 (2009-12-01), GB, pages 1675 - 1713, ISSN: 0003276282
Attorney, Agent or Firm:
田村 恭生
鮫島 睦
品川 永敏
森本 靖