Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
抗原の消失を促進する、FcRnに対するアフィニティーが変更された抗体
Document Type and Number:
Japanese Patent JP2013528354
Kind Code:
A
Abstract:
An objective of the present invention is to provide methods for facilitating antigen-binding molecule-mediated antigen uptake into cells, methods for facilitating the reduction of antigen concentration in plasma, methods for increasing the number of antigens to which a single antigen-binding molecule can bind, methods for improving pharmacokinetics of antigen-binding molecules, antigen-binding molecules improved for facilitated antigen uptake into cells, antigen-binding molecules capable of facilitating the reduction of antigen concentration in plasma, antigen-binding molecules capable of repeatedly binding to antigens, antigen-binding molecules with improved pharmacokinetics, pharmaceutical compositions comprising such an antigen-binding molecule, and methods for producing those described above. The present inventors discovered that antigen uptake into cells is facilitated by an antibody having human FcRn-binding activity at the plasma pH and a lower antigen-binding activity at the early endosomal pH than at the plasma pH; such antibodies can increase the number of antigens to which a single antibody molecule can bind; the reduction of antigen in plasma can be facilitated by administering such an antibody; and antibody pharmacokinetics can be improved by using such antibodies.

Inventors:
Tomoyuki Ikawa
Shinya Ishii
Atsuhiko Maeda
Takashi Nakai
Application Number:
JP2012535527A
Publication Date:
July 11, 2013
Filing Date:
March 30, 2011
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C12N15/09; A61K39/395; A61P43/00; C07K16/28; C07K16/46; C12P21/08; G01N33/15; G01N33/50; G01N33/531
Foreign References:
WO2009125825A12009-10-15
Other References:
JOURNAL OF IMMUNOLOGY. 2010 FEB, VOL.184, NO.4, P.1968-1976, JPN6013016363, ISSN: 0002501589
NATURE BIOTECHNOLOGY. 2010 FEB, VOL.28, NO.2, P.157-159,SUPPLEMENTARY INFORMATION, JPN6013016365, ISSN: 0002501590
THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2001, VOL.276, NO.9, P.6591-6604, JPN6013016367, ISSN: 0002501591
JOURNAL OF IMMUNOLOGY. 2009, VOL.182, NO.12, P.7663-7671, JPN6013016368, ISSN: 0002501592
CLINICAL CHEMISTRY. 1993, VOL.39, NO.9, P.1988-1997, JPN6013016369, ISSN: 0002501593
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto