Title:
ヒト抗菌ペプチドの分泌を促進する新規化合物、その製造方法及びこれを有効成分として含有する組成物
Document Type and Number:
Japanese Patent JP2013536221
Kind Code:
A
Abstract:
The present invention relates to a novel compound having an acceleration effect on the secretion of human ² -defensin, LL-37, which is a human-derived anti-microbial peptide, a method for preparing same, and a composition for accelerating the secretion of anti-microbial peptide having same as an active ingredient, and the compound and the composition using same of the present invention enhance the anti-microbial effect and the immunity control effect that the anti-microbial peptide has in the body by accelerating the secretion of the anti-microbial peptide in the body. The composition having the compound as an active ingredient of the present invention accelerates the secretion of innate anti-microbial peptide in the tissues and the organs in the body including the skin and can be administered through various courses including external application and oral administration, overcomes the problem of safety, the problem of resistant bacteria development, and the limitations of administration courses in a conventional anti-microbial agent, and demonstrates effective anti-microbial action.
Inventors:
Park Byun-Dog
Version-Fun
Jon Se-kyo
Guy Hyung-Sub
Version-Fun
Jon Se-kyo
Guy Hyung-Sub
Application Number:
JP2013525796A
Publication Date:
September 19, 2013
Filing Date:
August 27, 2010
Export Citation:
Assignee:
Neo Farm Company, Limited
International Classes:
A61K31/198; A61K9/06; A61K9/08; A61K9/10; A61K9/12; A61K9/14; A61K9/20; A61K38/00; A61P31/04; C07C233/51
Domestic Patent References:
| JP2004049498A | 2004-02-19 | |||
| JPH06227958A | 1994-08-16 | |||
| JP2006528935A | 2006-12-28 |
Foreign References:
| DE102008031556A1 | 2009-04-30 | |||
| WO2009044248A2 | 2009-04-09 | |||
| KR20110005419A | 2011-01-18 |
Other References:
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YASUO ARIYOSHI, ET AL.: "Structure-activity relationships of N-β-phenylpropionyl-L-tyrosine and its derivatives on the inhib", BRITISH JOURNAL OF PHARMACOLOGY, vol. 77, no. 4, JPN6014027015, December 1982 (1982-12-01), pages 631 - 639, ISSN: 0002844553
HEINRICH HUHNERFUSS, ET AL.: "Role of Hydrogen Bond and Metal Complex Formation for Chiral Discrimination in Amino Acid Monolayers", LANGMUIR, vol. 12, no. 10, JPN6014027017, 1996, pages 2561 - 2569, ISSN: 0002844554
TIMOTHY K. FINCHER, ET AL.: "In Vitro Evaluation of a Series of N-Dodecanoyl-L-amino Acid Methyl Esters as Dermal Penetration Enh", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 85, no. 9, JPN6014027019, September 1996 (1996-09-01), pages 920 - 923, ISSN: 0002844555
SAVVAS N. GEORGIADES, ET AL.: "Synthetic libraries of tyrosine-derived bacterial metabolites", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 10, JPN6014027020, 15 May 2008 (2008-05-15), pages 3117 - 3121, XP022669512, ISSN: 0002885867, DOI: 10.1016/j.bmcl.2007.10.058
S. Y. MHASKAR, ET AL.: "Synthesis of N-Acyl Amino Acids and Correlation of Structure with Surfactant Properties of Their Sod", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 67, no. 12, JPN6014027021, 1990, pages 1015 - 1019, XP008165315, ISSN: 0002885868, DOI: 10.1007/BF02541868
SEAN F. BRADY, ET AL.: "Long-Chain N-Acyltyrosine Synthases from Environmental DNA", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 70, no. 11, JPN7014001963, November 2004 (2004-11-01), pages 6865 - 6870, XP055083151, ISSN: 0002885869, DOI: 10.1128/AEM.70.11.6865-6870.2004
MICHAEL E. JUNG, ET AL.: "Facile chemical synthesis of S,S-isodityrosine, a naturally-occurring cross-linking amino acid", TETRAHEDRON LETTERS, vol. 30, no. 32, JPN6014027024, 1989, pages 4211 - 4214, XP055115852, ISSN: 0002885870, DOI: 10.1016/S0040-4039(01)80692-4
YASUO ARIYOSHI, ET AL.: "Structure-activity relationships of N-β-phenylpropionyl-L-tyrosine and its derivatives on the inhib", BRITISH JOURNAL OF PHARMACOLOGY, vol. 77, no. 4, JPN6014027015, December 1982 (1982-12-01), pages 631 - 639, ISSN: 0002844553
HEINRICH HUHNERFUSS, ET AL.: "Role of Hydrogen Bond and Metal Complex Formation for Chiral Discrimination in Amino Acid Monolayers", LANGMUIR, vol. 12, no. 10, JPN6014027017, 1996, pages 2561 - 2569, ISSN: 0002844554
TIMOTHY K. FINCHER, ET AL.: "In Vitro Evaluation of a Series of N-Dodecanoyl-L-amino Acid Methyl Esters as Dermal Penetration Enh", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 85, no. 9, JPN6014027019, September 1996 (1996-09-01), pages 920 - 923, ISSN: 0002844555
SAVVAS N. GEORGIADES, ET AL.: "Synthetic libraries of tyrosine-derived bacterial metabolites", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 10, JPN6014027020, 15 May 2008 (2008-05-15), pages 3117 - 3121, XP022669512, ISSN: 0002885867, DOI: 10.1016/j.bmcl.2007.10.058
S. Y. MHASKAR, ET AL.: "Synthesis of N-Acyl Amino Acids and Correlation of Structure with Surfactant Properties of Their Sod", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 67, no. 12, JPN6014027021, 1990, pages 1015 - 1019, XP008165315, ISSN: 0002885868, DOI: 10.1007/BF02541868
SEAN F. BRADY, ET AL.: "Long-Chain N-Acyltyrosine Synthases from Environmental DNA", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 70, no. 11, JPN7014001963, November 2004 (2004-11-01), pages 6865 - 6870, XP055083151, ISSN: 0002885869, DOI: 10.1128/AEM.70.11.6865-6870.2004
MICHAEL E. JUNG, ET AL.: "Facile chemical synthesis of S,S-isodityrosine, a naturally-occurring cross-linking amino acid", TETRAHEDRON LETTERS, vol. 30, no. 32, JPN6014027024, 1989, pages 4211 - 4214, XP055115852, ISSN: 0002885870, DOI: 10.1016/S0040-4039(01)80692-4
Attorney, Agent or Firm:
Kazuko Fujita