Title:
新規抗体およびＴｒｅｇ枯渇抗体と免疫刺激性抗体との併用
Document Type and Number:
Japanese Patent JP2020528765
Kind Code:
A
Abstract:
癌の治療に使用するためのＴｒｅｇ枯渇抗４−１ＢＢ抗体またはＴｒｅｇ枯渇ＯＸ−４０抗体などの、腫瘍壊死因子受容体スーパーファミリー（ＴＮＦＲＳＦ）に属する標的に特異的に結合する抗体分子などの抗体分子から選択されるＴｒｅｇ枯渇抗体分子を最初に、次いで免疫刺激性抗４−１ＢＢ抗体または免疫刺激性ＯＸ−４０抗体などの免疫刺激性抗体分子の順次投与が記載されている。また、かかる順次投与に使用され得る新規抗４−１ＢＢ抗体および新規ＯＸ−４０抗体についても記載されている。【選択図】図１−１
Inventors:
Bjorn Frendeus
Linda Mortenson
Monica Senrich
Ingrid Teige
Stephen Baas
Eimen Al-Shamkuhani
Juliet Gray
Martin Glennie
Linda Mortenson
Monica Senrich
Ingrid Teige
Stephen Baas
Eimen Al-Shamkuhani
Juliet Gray
Martin Glennie
Application Number:
JP2020526685A
Publication Date:
October 01, 2020
Filing Date:
July 26, 2018
Export Citation:
Assignee:
Bio-Invent International Actie Borrag
Cancer Research Technology Limited
Cancer Research Technology Limited
International Classes:
C12N15/13; A61K39/395; A61P7/00; A61P15/00; A61P21/00; A61P25/00; A61P35/00; A61P43/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63
Foreign References:
| WO2016029073A2 | 2016-02-25 |
Other References:
Y.SHINDO, ET AL., ANTICANCER RESEARCH, vol. 35, JPN6022026057, 2015, pages 129 - 136, ISSN: 0004812810
S.CHEN, ET AL., CANCER IMMUNOLOGY RESEARCH, vol. Vol.3(2), JPN6022026059, 2015, pages 149 - 160, ISSN: 0004812811
"M.Remer, et al.", CANCER IMMUNOLOGY RESEARCH, vol. Vol.4, No.11, Supp., JPN6022026062, 2016, pages 046, ISSN: 0004812812
S.CHEN, ET AL., CANCER IMMUNOLOGY RESEARCH, vol. Vol.3(2), JPN6022026059, 2015, pages 149 - 160, ISSN: 0004812811
"M.Remer, et al.", CANCER IMMUNOLOGY RESEARCH, vol. Vol.4, No.11, Supp., JPN6022026062, 2016, pages 046, ISSN: 0004812812
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kumi Kitamura
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kumi Kitamura