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Title:
MICROFLUIDIC MODEL OF BLOOD BRAIN BARRIER
Document Type and Number:
Japanese Patent JP2021000133
Kind Code:
A
Abstract:
To provide culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby cells mimic a structure and function of a blood brain barrier.SOLUTION: Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems. In one embodiment, a microfluidic chip comprises two microchannels separated by a porous membrane having first and second surfaces, wherein neurons are cultured on the first or second surface.SELECTED DRAWING: None

Inventors:
JORDAN S KERNS
NORMAN WEN
CAROL LUCCHESI
CHRIS HINOJOSA
JACOB FRASER
GERALDINE HAMILTON
GAD VATINE
SAMUEL SANCES
CLIVE SVENDSEN
DANIEL LEVNER
DHRUV SAREEN
Application Number:
JP2020162997A
Publication Date:
January 07, 2021
Filing Date:
September 29, 2020
Export Citation:
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Assignee:
EMULATE INC
CEDARS SINAI MEDICAL CENTER
International Classes:
C12N5/077; C12M3/00; C12N5/079; C12N5/10
Foreign References:
US20080044847A12008-02-21
Other References:
ROSS HUNTER BOOTH, A MICROFLUIDIC IN VITRO MODEL OF THE BLOOD-BRAIN BARRIER, A DISSERTATION SUBMITTE, JPN6019024540, 2014, ISSN: 0004609241
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita