Title:
中皮細胞遺伝子療法
Document Type and Number:
Japanese Patent JP3466194
Kind Code:
B2
Abstract:
Methods and pharmaceutical compositions for modifying the mesothelial cells of a mammalian recipient in situ are provided. The methods include forming a mesothelial cell expression system n vivo or ex vivo and administering the expression system to the mammalian recipient (by way of the body cavities normally lined by mesothelial cells). The mesothelial cell expression system is useful for the localized and systemic delivery of therapeutic agents in situ.
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Inventors:
ジャックマン,ロバート・ウィリアム
ショックリー,タイ・ロバート
ナギー,ジャニス・アン
ショックリー,タイ・ロバート
ナギー,ジャニス・アン
Application Number:
JP50295095A
Publication Date:
November 10, 2003
Filing Date:
June 15, 1994
Export Citation:
Assignee:
ベス・イスラエル・ホスピタル・アソシエーション
International Classes:
C12N15/09; A61K31/70; A61K35/12; A61K48/00; A61P35/00; C07K14/61; C12N5/00; C12N5/071; C12N5/10; C12N15/18; C12N15/85; A61K38/00; C12R1/91; (IPC1-7): C12N15/09; A61K35/12; A61K48/00; C12N5/10
Other References:
Am J Respir Cell Mol Biol.,Vol.8,No.2,pp.214−221(1993 Feb)
Gene Ther.,Vol.2(6),pp.393−401(1995)
J Natl Cancer Inst,Vol.81,No.12,pp.945−948(1989)
Gene Ther.,Vol.2(6),pp.393−401(1995)
J Natl Cancer Inst,Vol.81,No.12,pp.945−948(1989)
Attorney, Agent or Firm:
社本 一夫 (外5名)