環状アミン誘導体、およびその薬剤としての使用法

Title:

環状アミン誘導体、およびその薬剤としての使用法

Document Type and Number:

Japanese Patent JP3786578

Kind Code:

B2

Abstract:

A compound represented by general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. Since these compounds inhibit the action of chemokines such as MIP-1 alpha and/or MCP-1 on target cells, they may be useful as a therapeutic drug and/or preventative drug in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.

Inventors:

Shioda Tatsuki
Kenichiro Kataoka
Minoru Imai
Takaharu Tsutsumi
Masaki Sudo
Ryo Togawa
Moriya Takuya
Naohiko Haneda
Yumiko Muroka
Osamu Takenouchi
Minoru Furuya
Noriaki Endo
Christine M. Turby
Wilna Molly
Steven El. Tague

Application Number:

JP2000521070A

Publication Date:

June 14, 2006

Filing Date:

November 17, 1998

Export Citation:

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Assignee:

Teijin Pharma Limited

International Classes:

A61K31/445; A61K31/40; C07D223/02; A61K31/4025; A61K31/404; A61K31/4184; A61K31/422; A61K31/427; A61K31/433; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61K31/4468; A61K31/4525; A61K31/4535; A61K31/454; A61K31/4545; A61K31/55; A61P1/00; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P43/00; C07D207/09; C07D207/14; C07D207/325; C07D207/34; C07D207/416; C07D209/08; C07D209/42; C07D211/26; C07D211/56; C07D211/58; C07D213/65; C07D213/75; C07D213/81; C07D213/82; C07D231/14; C07D231/16; C07D235/16; C07D239/52; C07D249/18; C07D261/08; C07D263/56; C07D263/58; C07D271/06; C07D285/14; C07D307/14; C07D307/68; C07D317/50; C07D317/60; C07D319/18; C07D333/16; C07D333/20; C07D333/38; C07D333/42; C07D333/68; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D405/06; C07D405/12; C07D405/14; C07D407/12; C07D409/06; C07D409/12; C07D409/14; C07D413/06; C07D413/12; C07D413/14; C07D417/06; C07D417/12; C07D487/04; C07D495/04; C07D513/04; C07D207/32; C07D207/40

Domestic Patent References:

JP2001525809A
JP10226689A

Foreign References:

GB2106108A

Other References:

LAWRENCE R. Michael,Automated Synthesis and Purifivation of Amides: Ezploitation of Automated Solid Phase Extraction in ,Synthsis,1997年,No.5,p.553-558

Attorney, Agent or Firm:

Hideko Mihara

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