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Title:
硫黄置換スルホニルアミノカルボン酸N-アリールアミド、それらの製造、それらの使用、及びそれらを含む医薬製剤
Document Type and Number:
Japanese Patent JP3786579
Kind Code:
B2
Abstract:
The present invention relates to compounds of the formula I wherein A 1 , A 2 , R 1 , R 2 , R 3 , X and n are as defined in the claims, which are valuable pharmaceutically active compounds for the therapy and prophylaxis of diseases, for example of cardiovascular diseases such as hypertension, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis. The compounds of the formula I are capable of modulating the body's production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of the formula I, to their use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of the formula I.

Inventors:
Urzla Schindler
Karl Shenafinger
Hartmut Straubel
Application Number:
JP2000559082A
Publication Date:
June 14, 2006
Filing Date:
June 25, 1999
Export Citation:
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Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C07C311/46; A61K31/18; A61K31/275; A61K31/38; A61K31/381; A61K31/40; A61K31/401; A61K31/403; A61K31/404; A61K31/415; A61K31/4166; A61K31/4184; A61K31/42; A61K31/426; A61K31/428; A61K31/435; A61K31/44; A61K31/4402; A61K31/4409; A61K31/4427; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/445; A61K31/4453; A61K31/4462; A61K31/4535; A61K31/454; A61K31/4545; A61K31/4725; A61K31/495; A61K31/496; A61K31/505; A61K31/506; A61K31/5355; A61K31/5375; A61K31/5377; A61K31/54; A61K31/541; A61K31/551; A61P1/16; A61P3/10; A61P7/02; A61P9/00; A61P9/02; A61P9/04; A61P9/10; A61P9/12; A61P11/06; A61P13/12; A61P15/10; A61P25/28; A61P43/00; C07C311/21; C07C311/51; C07C311/58; C07C317/40; C07C323/41; C07C323/42; C07C323/52; C07C323/60; C07C331/12; C07D207/12; C07D207/16; C07D207/48; C07D209/10; C07D209/14; C07D211/54; C07D211/96; C07D213/42; C07D213/71; C07D213/78; C07D213/80; C07D213/82; C07D215/36; C07D221/20; C07D231/18; C07D231/42; C07D233/42; C07D233/84; C07D235/18; C07D235/28; C07D239/06; C07D239/42; C07D243/08; C07D261/10; C07D261/16; C07D265/30; C07D277/04; C07D277/10; C07D277/20; C07D277/36; C07D277/46; C07D277/54; C07D277/64; C07D295/08; C07D295/22; C07D295/26; C07D333/34; C07D333/38; C07D333/40; C07D333/62; C07D333/70; C07D401/12; C07D409/12; C07D413/12
Domestic Patent References:
JP9043786A
JP7056293A
JP5027380A
JP4285955A
Attorney, Agent or Firm:
Chika Takagi
Nishimura Kosuke
Hiroshi Sugimoto