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Document Type and Number:
Japanese Patent JP4355924
Kind Code:
The invention relates to chimeric proteins comprising an artificial sequence for cleavage by thrombin, in which the activation peptide is fibrinopeptide A. Preferably, said chimeric proteins are derived from the zymogen of a serine protease such as PC or FX, by replacing the activation peptide of said zymogen with fibrinopeptide A, or a portion thereof, comprising at least amino acids P10 to P1 of said fibrinopeptide.

Le Bonique, Bernard
Marc, Pierre-Emanuel
Luban, Birginie
Carmel, Clair
Bianthoni, Elsa
Ayrche, Martin
Application Number:
Publication Date:
November 04, 2009
Filing Date:
October 18, 2002
Export Citation:
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Institut Nacional de la Sant'Edral Cherche Medical
International Classes:
C07K14/745; C12N15/09; A61K31/7088; A61K38/00; A61K38/36; A61K48/00; A61P7/02; A61P7/04; C07K14/75; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/64; C12N15/57; C12P21/06
Other References:
J. Biol. Chem., vol. 264, pages 14298-14304 (1989)
Thromb. Res., vol. 97, pages 51-67 (2000)
J. Biol. Chem., vol. 269, pages 15989-15992 (1994)
Attorney, Agent or Firm:
Eiji Saegusa
Kakehi Yuro
Takeshi Ohara
Kenji Saito
Jun Fujii
Hitoshi Seki
Mutsuko Nakano