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Title:
インビボ許容性の向上した製剤
Document Type and Number:
Japanese Patent JP4367798
Kind Code:
B2
Abstract:
Compositions containing a glycosylated drug derivative of formula (I) and/or its salts, a carrier and optionally divalent ions, is new. G-Y-(C(=Y)-X)p-W(R)n-X-C(=Y)-A (I) Also claimed is the production of the preparation by processing the ingredients into a pharmaceutical dosage form. G = enzymatically cleavable poly-, oligo- or monosaccharide residue; W = aromatic or heteroaromatic residue, aliphatic residue containing conjugated double bonds or amino acid residue which cyclises after cleavage of G; R = H, Me, OMe, COOH, CN, COOMe, OH, NO2, F, Cl, Br, sulphonyl, sulphonamide or (1-4C alkyl)-sulphonamide; p = 0 or 1; n = integer; X = O, NH, methyleneoxy, methyleneamino or methylene-(1-4C) alkylamino; Y = O or NH; and A = biologically active agent bonded via a hydroxy, amino or imino group.

Inventors:
クラウス・ボスレト
イエルク・ツエヒ
マンフレト・ゲルケン
ライナー・シユトラウプ
マテイーアス・ブルムリヒ
Application Number:
JP13323198A
Publication Date:
November 18, 2009
Filing Date:
May 15, 1998
Export Citation:
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Assignee:
ヘキスト・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング
International Classes:
A61K47/26; C07H15/20; A61K9/20; A61K9/48; A61K31/047; A61K31/70; A61K31/7004; A61K31/7028; A61K31/7034; A61K31/704; A61K31/715; A61K47/02; A61K47/10; A61K47/36; A61K47/48; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07H5/06; C07H15/244; C07H15/252
Domestic Patent References:
JP10130295A
JP10001495A
JP9012591A
JP7149667A
JP6506687A
JP6293665A
JP6128162A
Attorney, Agent or Firm:
結田 純次
三輪 昭次
竹林 則幸
高木 千嘉
西村 公佑