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Document Type and Number:
Japanese Patent JP4428693
Kind Code:
This invention provides alternative bone implants that have high bioadaptability and enable rapid bone regeneration. Specifically, this invention relates to implants consisting of a bioadaptable material comprising cells transfected with growth factor genes. Such implants are produced by inoculating bone-marrow-derived cells transfected with the genes of vascular endothelial growth factors (VEGF) into a bioadaptable material, such as porous ceramics, and culturing them.

Uemura Tokiko
Tetsuya Tateishi
Kazuya Matsumoto
Hiroko Kojima
Application Number:
Publication Date:
March 10, 2010
Filing Date:
October 21, 2002
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National Institute of Advanced Industrial Science and Technology
Japan Science and Technology Agency
International Classes:
A61L27/00; A61K38/19; A61L27/12; A61L27/18; A61L27/22; A61L27/24; A61L27/38; A61L27/54; A61L27/58; C12N5/074; A61K35/12; C12N15/09
Domestic Patent References:
Other References:
再生医学~ティッシュエンジニアリングの基礎から最先端技術まで~,株式会社 エヌ・ティー・エス,2002年 1月31日,p.680-686
J. Bone Miner. Res.,1997年,Vol.12, No.10,p.1606-1614
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita

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