Title:
アポトーシスを誘導するサイトカイン
Document Type and Number:
Japanese Patent JP4435304
Kind Code:
B2
Abstract:
A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.
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Inventors:
Willie, Stephen Earl
Goodwin, Raymond G
Goodwin, Raymond G
Application Number:
JP50453097A
Publication Date:
March 17, 2010
Filing Date:
June 25, 1996
Export Citation:
Assignee:
IMMUNEX CORPORATION
International Classes:
C12N15/09; A61K38/00; A61K38/19; A61P31/12; A61P35/00; C07K14/52; C07K14/705; C07K16/24; C07K16/28; C12N15/17; C12N15/19; C12N15/63; C12P21/02; C12P21/08; C07K
Other References:
Cell, 1993年, Vol.75, p.1169-1178
Attorney, Agent or Firm:
Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Reiko Izumiya
Shosuke Imai
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Reiko Izumiya