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Title:
鎮痛性化合物、それらの合成およびそれらを含む薬学的組成物
Document Type and Number:
Japanese Patent JP4568726
Kind Code:
B2
Abstract:
New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These compounds surprisingly possess high analgesic activity with little hepatotoxic effect, making them more useful than conventional non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of chronic pain.

Inventors:
Bazan, Nicholas G.
Baccarino, Anthony
Sankel, Carlos
Buila, Julio Alvarez
Application Number:
JP2006534463A
Publication Date:
October 27, 2010
Filing Date:
October 12, 2004
Export Citation:
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Assignee:
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
International Classes:
C07C311/19; A61K31/192; A61K31/485; A61K45/00; A61P29/00; C07C303/36
Domestic Patent References:
JP11509520A
JP2000103778A
Foreign References:
WO2002100819A1
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita