Title:
S1P(Edg)受容体作働薬としての(3,4-ジ置換)プロパンカルボン酸
Document Type and Number:
Japanese Patent JP4773972
Kind Code:
B2
Abstract:
The present invention encompasses compounds of Formula I: as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes in secondary lymphoid tissues, and enhancing vascular integrity. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention.
Inventors:
Corandrea, Vincent The Ray
Doherty, Giyo A
Hale, Jefrey Jay
Huo, Pay
Regietsk, Eileen Yee
Toss, Leslie
Bahual, Petr
Yang, Lin
Doherty, Giyo A
Hale, Jefrey Jay
Huo, Pay
Regietsk, Eileen Yee
Toss, Leslie
Bahual, Petr
Yang, Lin
Application Number:
JP2006545810A
Publication Date:
September 14, 2011
Filing Date:
December 13, 2004
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
C07D271/06; A61K31/4245; A61K31/427; A61K31/443; A61K31/506; C07D271/10; C07D285/12; C07D413/04; C07D413/10; C07D413/14; C07D417/04; A61K31/433; A61K31/4439; A61K31/5377; A61P1/02; A61P1/04; A61P1/16; A61P3/10; A61P7/00; A61P7/06; A61P9/00; A61P9/04; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P17/14; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/06; A61P25/28; A61P27/12; A61P29/00; A61P31/14; A61P31/20; A61P35/00; A61P37/02; A61P37/06; A61P37/08
Domestic Patent References:
| JP5221999A |
Other References:
Zhurnal Organicheskoi Khimii,1985年,Vol.21, No.7,pp.1560-1564
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura