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Patent Searching and Data


Title:
S1P(Edg)受容体作働薬としての(3,4-ジ置換)プロパンカルボン酸
Document Type and Number:
Japanese Patent JP4773972
Kind Code:
B2
Abstract:
The present invention encompasses compounds of Formula I: as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes in secondary lymphoid tissues, and enhancing vascular integrity. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention.

Inventors:
コランドレーア,ビンセント・ジエイ
ドハーテイ,ジヨージ・エイ
ヘイル,ジエフリー・ジエイ
フオ,ぺイ
レジエツク,アイリーン・イー
トス,レスリー
バフアル,ペトル
ヤン,リン
Application Number:
JP2006545810A
Publication Date:
September 14, 2011
Filing Date:
December 13, 2004
Export Citation:
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Assignee:
メルク・シャープ・エンド・ドーム・コーポレイション
International Classes:
C07D271/06; A61K31/4245; A61K31/427; A61K31/443; A61K31/506; C07D271/10; C07D285/12; C07D413/04; C07D413/10; C07D413/14; C07D417/04; A61K31/433; A61K31/4439; A61K31/5377; A61P1/02; A61P1/04; A61P1/16; A61P3/10; A61P7/00; A61P7/06; A61P9/00; A61P9/04; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P17/14; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/06; A61P25/28; A61P27/12; A61P29/00; A61P31/14; A61P31/20; A61P35/00; A61P37/02; A61P37/06; A61P37/08
Domestic Patent References:
JP5221999A
Foreign References:
Attorney, Agent or Firm:
川口 義雄
小野 誠
渡邉 千尋
金山 賢教
大崎 勝真
坪倉 道明