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Title:
安定化されたヒトIgG4抗体
Document Type and Number:
Japanese Patent JP4958555
Kind Code:
B2
Abstract:
A highly stable mutant of human IgG4 antibody is provided. Such antibody is an antibody in which the CH3 domain of human IgG4 is substituted with the CH3 domain of human IgG1 and which exhibits inhibited aggregate formation, an antibody in which the CH3 and CH2 domains of human IgG4 are substituted with the CH3 and CH2 domains of human IgG1, respectively, or an antibody in which arginine at position 409 indicated in the EU index proposed by Kabat et al. of human IgG4 is substituted with lysine and which exhibits inhibited aggregate formation.

Inventors:
高橋 信明
吉田 英明
Application Number:
JP2006536409A
Publication Date:
June 20, 2012
Filing Date:
September 22, 2005
Export Citation:
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Assignee:
協和発酵キリン株式会社
International Classes:
C07K16/28; A61K39/395; A61P9/10; A61P13/12; A61P25/28; A61P29/00; A61P35/00; A61P37/06; C12N15/09; C12P21/08; C12N5/10
Domestic Patent References:
JP2002512776A
Foreign References:
WO2002088186A1
Attorney, Agent or Firm:
小栗 昌平
本多 弘徳
市川 利光
古館 久丹子