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Title:
アクリル酸誘導体の遷移金属触媒不斉水素化方法および不斉遷移金属触媒反応用の新規な触媒系
Document Type and Number:
Japanese Patent JP5147410
Kind Code:
B2
Abstract:
A process for transition metal-catalyzed, asymmetric hydrogenation of acrylic acid derivatives of the formula (I) in which R1 is H or an optionally substituted alkyl, aryl or heteroaryl radical, R2 is an optionally substituted alkyl, aryl or heteroaryl radical, and R3 is H or a C1-C6-alkyl radical, which comprises hydrogenating compounds of the formula (I), optionally in a solvent, in the presence of one or more hydrogen donors, using a catalyst system which comprises a transition metal from the group of ruthenium, rhodium and iridium and a combination of a chiral phosphorus ligand of the formula (II) in which Cn, together with the two oxygen atoms and the phosphorus atom, forms an optionally substituted ring having from 2 to 6 carbon atoms and R4 is an optionally substituted alkyl, aryl, alkoxy or aryloxy radical or NR5R6 where R5 and R6 may each independently be H or an optionally substituted alkyl, aryl, aralkyl or alkaryl radical, or, together with the nitrogen atom, may form a ring, and an achiral phosphine ligand of the formula (III) in which R is an optionally substituted alkyl or aryl radical, to the corresponding compounds of the formula (IV) in which R1, R2 and R3 are each as defined above, and also a novel catalyst system for asymmetric transition metal catalysis.

Inventors:
ブーガーズ, ジェロエン
フェルファー, ウルフライド
コトタウス, マルティナ
デ ヴリエス, アンドレアス, エイチ., エム.
デ ヴリエス, ヨハネス, ジー.
レフォート, ローレント
ステインバウアー, ジャーハード
Application Number:
JP2007548711A
Publication Date:
February 20, 2013
Filing Date:
December 05, 2005
Export Citation:
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Assignee:
ディーエスエム ファイン ケミカルズ オーストリア エヌエフジー ゲーエムベーハー ウント ツェーオー カーゲー
International Classes:
C07C51/36; C07C59/64; C07B61/00
Domestic Patent References:
JP2004502663A
JP7242586A
JP63239245A
JP3157346A
JP3275691A
JP11080179A
JP2003176293A
JP2003535834A
JP2004502543A
Foreign References:
WO2004035208A1
Attorney, Agent or Firm:
山田 行一
池田 成人
野田 雅一
清水 義憲



 
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