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Title:
アポトーシス促進剤
Document Type and Number:
Japanese Patent JP5147688
Kind Code:
B2
Abstract:
Macrocyclic compounds of formula (I), in which B1 and X1 taken together are alkylene which is unsubstituted or substituted with ═O and having one CH2 moiety unreplaced or replaced with CH═CH, O, NH or N(alkyl), which inhibit the activity of antiapoptotic Bcl-2 family protein members, compositions containing the compounds and methods of treating diseases during which are expressed one or more than one of an anti-apoptotic family protein member are disclosed.

Inventors:
エルモア,ステイーブン
リンチ,クリストフアー
ワン,シールー
Application Number:
JP2008513542A
Publication Date:
February 20, 2013
Filing Date:
May 17, 2006
Export Citation:
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Assignee:
ABBOTT LABORATORIES
International Classes:
C07C323/25; A61K31/18; A61K31/438; A61K31/445; A61K31/495; A61K31/496; A61P35/00; A61P35/02; A61P43/00; C07D211/14; C07D211/48; C07D221/20; C07D295/14; C07D309/04
Domestic Patent References:
JP2007511530A
JP2004529852A
Foreign References:
WO2005049593A1
Attorney, Agent or Firm:
特許業務法人川口國際特許事務所
川口 義雄
小野 誠
渡邉 千尋
金山 賢教
大崎 勝真
坪倉 道明



 
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