Title:
外来抗原に対する宿主の寛容を壊すためのキメラ抗原
Document Type and Number:
Japanese Patent JP5200201
Kind Code:
B2
Abstract:
Disclosed herein are compositions and methods for eliciting immune responses against antigens. In particular, the compounds and methods elicit immune responses against foreign antigens that are otherwise recognized by the host as "self' antigens, thus breaking host tolerance to those antigens. Presenting the host immune system with a chimeric antigen comprising an immune response domain and a target binding domain, wherein the target binding domain comprises an antibody fragment, enhances the immune response against the foreign or tolerated antigen. Antigen presenting cells take up, process, and present the chimeric antigen, eliciting both a humoral and cellular immune response against the desired antigen.
Inventors:
George, Rajan
Tyrrell, Lorne
Nujaim, Antoine
Wang, Dakun
Ma, Alan
Tyrrell, Lorne
Nujaim, Antoine
Wang, Dakun
Ma, Alan
Application Number:
JP2006522192A
Publication Date:
June 05, 2013
Filing Date:
August 06, 2004
Export Citation:
Assignee:
Paladin Labs Inc.
International Classes:
C07K19/00; A61K39/29; A61K39/385; A61K39/395; A61P31/12; A61P31/20; C07K14/02; C07K14/18; C07K16/08; C07K16/46; C12N1/19; C12N5/0784; C12N5/10; C12N15/09; C12N15/13; C12N15/36; C12P21/02; A61K38/095; A61K39/00
Domestic Patent References:
| JP6502410A |
Foreign References:
| WO2001007081A1 | ||||
| WO2000020460A1 | ||||
| US20010048922 |
Other References:
Cancer Research,2001年,Vol.61,p.3704-3711
Eur.J.Immunol.,2000年,Vol.30,p.1714-1723
Eur.J.Immunol.,2000年,Vol.30,p.1714-1723
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga
Manami Sawamoto
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga
Manami Sawamoto