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Document Type and Number:
Japanese Patent JP5215975
Kind Code:
The present invention relates to acylated indanyl amines according to the general formula (I) wherein R1-R4 have the meanings given in the description, A is CH2, CHOH or CH—(C1-C3-alkyl), B is CH2 or CH—(C1-C3-alkyl), and R5 is an aryl or heteroaryl group, possibly substituted by the substituents listed in the description. These compounds are useful in the upregulation of endothelial nitric oxide synthase (eNOS), and may therefore be useful for the manufacture of medicaments for the treatment of cardiovascular diseases, stable or unstable angina pectoris, coronary heart disease, Prinzmetal angina, acute coronary syndrome, heart failure, myocardial infarction, stroke, thrombosis, peripheral artery occlusive disease, endothelial dysfunction, atherosclerosis, restenosis, endothelial damage after PTCA, hypertension, essential hypertension, pulmonary hypertension, secondary hypertension, renovascular hypertension, chronic glomerulonephritis, erectile dysfunction, ventricular arrhythmia, diabetes or diabetes complications, nephropathy or retinopathy, angiogenesis, asthma bronchiale, chronic renal failure, cirrhosis of the liver, osteoporosis, restricted memory performance, a restricted ability to learn, or for the lowering of cardiovascular risk of postmenopausal women or after intake of contraceptives.

Hartmut Straubel
Pauls Wohlfalt
Arena safarova
Armin Walther
Terri Suzuki
Lamaringa M. Darrani Pragada
Karl Schenafinger
Application Number:
Publication Date:
June 19, 2013
Filing Date:
October 23, 2009
Export Citation:
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Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C07C233/04; A61K9/02; C07C233/65; A61K9/06; A61K9/08; A61K9/10; A61K9/107; A61K9/12; A61K9/16; A61K9/20; A61K9/28; A61K9/30; A61K9/36; A61K9/48; A61K9/50; A61K9/72; A61K31/165; A61K31/166; A61K31/18; A61K31/194; A61K31/222; A61K31/341; A61K31/343; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/40; A61K31/404; A61K31/405; A61K31/415; A61K31/416; A61K31/4172; A61K31/4184; A61K31/4192; A61K31/42; A61K31/4245; A61K31/427; A61K31/433; A61K31/435; A61K31/4365; A61K31/437; A61K31/44; A61K31/4406; A61K31/4409; A61K31/4425; A61K31/4439; A61K31/455; A61K31/47; A61K31/473; A61K31/4965; A61K31/497; A61K31/498; A61K31/501; A61K31/502; A61K31/505; A61K31/538; A61K31/5513; A61P1/16; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P15/10; A61P19/10; A61P25/28; A61P43/00; C07C233/58; C07C233/64; C07C233/66; C07C233/67; C07C233/74; C07C233/76; C07C235/42; C07C235/44; C07C235/54; C07C235/82; C07C235/84; C07C237/28; C07C237/30; C07C237/38; C07C237/42; C07C237/52; C07C255/57; C07C255/60; C07C309/04; C07C309/66; C07C309/73; C07C311/08; C07C311/16; C07C311/21; C07C311/42; C07C317/44; C07C323/42; C07C323/56; C07C323/62; C07D207/325; C07D207/327; C07D207/34; C07D209/08; C07D209/42; C07D213/56; C07D213/81; C07D213/82; C07D215/48; C07D215/52; C07D219/04; C07D231/14; C07D231/56; C07D233/90; C07D235/08; C07D237/28; C07D239/26; C07D239/42; C07D241/24; C07D241/44; C07D243/14; C07D249/04; C07D249/06; C07D249/18; C07D261/18; C07D265/36; C07D271/08; C07D277/20; C07D277/56; C07D285/06; C07D295/12; C07D295/185; C07D307/68; C07D307/78; C07D307/79; C07D307/84; C07D307/85; C07D317/60; C07D317/68; C07D319/16; C07D319/18; C07D333/24; C07D333/38; C07D333/40; C07D333/68; C07D333/70; C07D401/06; C07D403/04; C07D405/04; C07D471/04; C07D495/04
Domestic Patent References:
Foreign References:
Other References:
Journal of the Chemical Society. Perkin Transactions. 1,2000年,No.18,p.3096-3106
Tetrahedron Letters,1998年,Vol.39,p.497-500
Justus Liebigs Annalen der Chemie,1971年,Vol.743,p.42-9
Journal of Mathematical Chemistry,2001年,Vol.44,p.2638-40
Bulletin of the Korean Chemical Society,2001年,Vol.22, No.4,p.4014
Attorney, Agent or Firm:
Junji Yuda
Shoji Miwa
Noriyuki Takebayashi

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