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Title:
SMOアンタゴニストであるトリアゾール誘導体
Document Type and Number:
Japanese Patent JP5498936
Kind Code:
B2
Abstract:
The present invention provides a method for the treatment or prevention of conditions which can be ameliorated by Smo antagonism, which method comprises administration to a patient in need thereof of an effective amount of a compound of formula I or a composition comprising a compound of formula I: or a pharmaceutically acceptable salt or solvate thereof; wherein: 2 of X, Y and Z represent nitrogen atoms, and the other represents an oxygen atom; R1 and R2 are taken together with the atom to which they are attached and represent a cyclobutyl ring, optionally substituted with 1-2 fluorine atoms, and R3 represents hydrogen or a fluorine atom; or R1 represents methyl, R2 represents methyl or a fluorine atom and R3 represents a fluorine atom.

Inventors:
Balcovec, James, M
Thieringer, Rolf
Wadel, shaman, tee
Application Number:
JP2010504069A
Publication Date:
May 21, 2014
Filing Date:
April 15, 2008
Export Citation:
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Assignee:
Merck Sharp & Dohme Corp.
International Classes:
A61K31/4245; A61P35/00; A61P35/02; C07D413/08
Domestic Patent References:
JP2006513266A
JP2009512704A
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yasufumi Shiroyama
Kenji Ando