Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
生物活性を強化した抗体改変体
Document Type and Number:
Japanese Patent JP5598894
Kind Code:
B2
Abstract:
The present inventors generated modified antibodies in which several Fc domains are linked in tandem to the C terminus of the heavy chain, and modified antibodies in which Fc domains are linked in tandem via spacers, and measured the affinity for Fc receptors, CDC activity, and ADCC activity. A previous report indicated that CDC activity is not enhanced by linking multiple Fcs. However, the modified antibodies of the present invention exhibited enhanced ADCC activity. The methods of the present invention enable provision of antibody pharmaceuticals having a marked therapeutic effect.

Inventors:
増保 Yasuhiko
Hiroaki Nagashima
Application Number:
JP2008502861A
Publication Date:
October 01, 2014
Filing Date:
March 02, 2007
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
Educational foundation Science University of Tokyo
General CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE
TEIJIN PHARMA, LTD.
International Classes:
C12N15/09; A61K39/395; A61P37/04; C07K16/18; C07K16/46; C12P21/08
Foreign References:
WO2004029207A22004-04-08
WO2005077981A22005-08-25
Other References:
JPN5010008747; STEVENSON G T: JOURNAL OF IMMUNOLOGY V158, 19970101, P2242-2250, AMERICAN ASSOCIATION OF IMMUNOLOGISTS
JPN6011059770; KAN, K.S. et al.: J. Immunol. Vol.166, 2001, pp.1320-1326
JPN5010008943; GREENWOOD J: THERAPEUTIC IMMUNOLOGY V1 N5, 19941001, P247-255, BLACKWELL SCIENTIFIC PUBL.
JPN6011059765; 田村隆明, 山本雅 編: 分子生物学イラストレイテッド 第2刷, 1998, 第159-160頁
JPN6011059767; 長島弘明, 増保安彦: 薬学雑誌 Vol.130, No.1, 2010, pp.49-54
JPN6012050543; CARTRON, G. et al.: Blood Vol.99, 2002, pp.754-758
JPN6012050545; WENG, W.-K. and LEVY, R.: J. Clin. Oncol. Vol.21, No.21, 2003, pp.3940-3947
Attorney, Agent or Firm:
Spring water Original aim
Shun Osakabe
Kazuya Kawamoto
Koichi Niimi



 
Previous Patent: 人体型ファントム

Next Patent: JPS5598895