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Title:
既知の薬理活性化合物の新たな用途
Document Type and Number:
Japanese Patent JP5735274
Kind Code:
B2
Abstract:
The present invention relates to the new use of alpha-ketoglutarate, amides, and salts and mixtures thereof for the manufacture of a pharmaceutical preparation or a food or feed supplement for the in vivo therapeutic improvement of blood vessel elasticity, in particular arterial elasticity in a subject in need thereof. Improving the blood vessel elasticity may be used in the for the treatment and/or prophylaxis of hypertension, pulmonary arterial hypertension, cardiovascular disease, retinal vascular disease, heart failure, atherosclerosis, ventricular hypertrophy, stroke, arterial aneurysm, kidney failure, nephrosclerosis and diseases related to hypertension.

Inventors:
ステファン・ゲー・ピエルシノウスキー
Application Number:
JP2010514699A
Publication Date:
June 17, 2015
Filing Date:
June 27, 2008
Export Citation:
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Assignee:
ENTRESS AB
International Classes:
A61K31/194; A61P9/00; A61P9/12
Domestic Patent References:
JP2000093096A
Foreign References:
WO2005123056A1
Attorney, Agent or Firm:
田村 恭生
鮫島 睦
新田 昌宏
呉 英燦