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Document Type and Number:
Japanese Patent JP5746860
Kind Code:
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.

Tessier, Pierre
Late, Silvana
Smil, David
Dejielle, robert
Ajamian, Alan
Chantilly, Eve, Andre
Dominguez, Ceria
Application Number:
Publication Date:
July 08, 2015
Filing Date:
April 09, 2008
Export Citation:
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Methyl Gene Incorporated
International Classes:
C07C259/06; A61K31/16; A61K31/165; A61K31/18; A61K31/343; A61K31/352; A61K31/36; A61K31/381; A61K31/397; A61K31/40; A61K31/403; A61K31/405; A61K31/407; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/4192; A61K31/426; A61K31/437; A61K31/438; A61K31/4406; A61K31/443; A61K31/4439; A61K31/445; A61K31/4453; A61K31/454; A61K31/4545; A61K31/47; A61K31/473; A61K31/495; A61K31/505; A61K31/506; A61K31/5375; A61K31/538; A61K31/54; A61K45/00; A61P3/10; A61P9/00; A61P25/08; A61P25/24; A61P29/00; A61P31/10; A61P31/12; A61P35/00; A61P37/00; C07C259/08; C07C311/19; C07C317/44; C07C323/20; C07C323/62; C07D207/09; C07D207/337; C07D209/08; C07D209/44; C07D209/94; C07D211/14; C07D211/34; C07D211/44; C07D213/56; C07D215/24; C07D219/04; C07D233/42; C07D235/16; C07D239/26; C07D239/38; C07D239/42; C07D249/04; C07D277/74; C07D279/12; C07D285/12; C07D295/08; C07D295/22; C07D307/81; C07D311/84; C07D319/16; C07D333/24; C07D401/04; C07D401/06; C07D409/04; C07D413/04; C07D413/14; C07D417/04; C07D471/04; C07D491/113; C07D493/08; C07D513/04
Domestic Patent References:
Other References:
Buraczewski, Krzysztof; Czerwinska, Elzbieta; Eckstein, Zygmunt; Grochowski, Edward; Kowalik, Romuald; Plenkiewicz, Jan,The properties and fungicidal activity of some aryl derivatives of hydroxamic acid,Przemysl Chemiczny,1964年,43(11),626-9
Eckstein, Zygmunt; Rusek, Dorota,Possible synthesis and use of diarylacetohydroximic chlorides,Przemysl Chemiczny ,1979年,58(5),235-8
KrennHrubec, Keris; Marshall, Brett L.; Hedglin, Mark; Verdin, Eric; Ulrich, Scott M.,Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors,Bioorganic and Medicinal Chemistry Letters ,2007年,17(10),2874-2878
Attorney, Agent or Firm:
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