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Title:
in situフォトバイオモジュレーションのための、非侵襲的エネルギーアップコンバージョン方法およびシステム
Document Type and Number:
Japanese Patent JP6300854
Kind Code:
B2
Abstract:
Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Inventors:
トゥアン・ヴォ−ディン
ジョナサン・ピー・スカフィディ
ヴェンカタ・ゴパル・レディ・チャダ
ブノワ・ローリー
ヤン・ジャン
モリー・ケイ・グレガス
イアン・エヌ・スタントン
ジョシュア・ティー・ステッチャー
マイケル・ジェイ・テリアン
ジェニファー・エアーズ
ジェンユアン・ジャン
スティーブン・ジョン・ノートン
フレデリック・エー・バーク
ハロルド・ワルダー
ザク・ファティ
ジョセフ・エイチ・シモンズ
Application Number:
JP2016058097A
Publication Date:
March 28, 2018
Filing Date:
March 23, 2016
Export Citation:
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Assignee:
イミュノライト・エルエルシー
DUKE UNIVERSITY
International Classes:
A61N5/06; A61K9/14; A61K41/00; A61K49/00; A61P35/00
Domestic Patent References:
JP2007536356A
JP2003522149A
JP5908396B2
Foreign References:
WO2008007290A1
WO2008121077A1
US20020127224
Attorney, Agent or Firm:
村山 靖彦
実広 信哉