Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
生物学的製剤の個別生成および体細胞を再プログラム化するための方法
Document Type and Number:
Japanese Patent JP6373459
Kind Code:
B2
Abstract:
Use invention provides a method for producing polypeptide protein products and nucleic acid products having reduced levels of antigenicity in an animal being treated with a biologic product. Somatic cells are isolated from an animal, transformed into pluripotent stem cells, transfected with a nucleic acid(s) of interest, and re-differentiated towards somatic cells known to be high level producers of the desired nucleic acid product. The invention can be used to derive a general cell line to treat populations, racial specific cell lines to treat ethnic groups, or patient specific cell lines to treat individuals. Additionally, the invention provides a method to allow induced pluripotent stem cells to be re-differentiated towards their somatic cell of origin so that the cells can be used to therapeutically treat an animal without resulting teratoma formation.

Inventors:
テレサ・ディー.・デイシェアー
Application Number:
JP2017127560A
Publication Date:
August 15, 2018
Filing Date:
June 29, 2017
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
エーブイエム・バイオテクノロジー・エルエルシー
International Classes:
C12N15/09; C12N5/0789; C12P21/02; C12P21/08
Domestic Patent References:
JP2002262879A
JP2010268789A
Foreign References:
WO2010117464A1
WO2009091543A1
US20080274125
WO2010022194A2
Attorney, Agent or Firm:
三好 秀和
伊藤 正和
原 裕子