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Document Type and Number:
Japanese Patent JP6556465
Kind Code:
The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to specific antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects. The invention also relates to fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly in therapy, to increase NK cell activity or cytotoxicity in subjects.

Solen Berg Paduk Jael
Alessandro Moretta
Mariella della Chisa
Pascal Andre
Laurent Ghattier
Peter Andreas Nikolai Rumelt Wagtman
Application Number:
Publication Date:
August 07, 2019
Filing Date:
March 04, 2015
Export Citation:
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Novo Nordisk Ar/S
Inate Pharma
University of Genoa
International Classes:
A61K39/395; A61P35/00; A61P35/02; C07K16/28; C12N5/0783; G01N33/569; A61K9/127
Foreign References:
Other References:
Blood、2002, Vol.100, No.12, pp.4098-4107
Hybridoma、1999, Vol.18, No.6, pp.521-527
Tissue Antigens、2000, Vol.55, No.Supplement 1, pp.80-81, N15
International Immunology、2001, Vol.13, No.8, pp.1043-1052
Attorney, Agent or Firm:
Kurata Masatoshi
Nobuhisa Nogawa