Title:
免疫原性の中東呼吸器症候群コロナウイルス（ＭＥＲＳ−ＣｏＶ）組成物および方法
Document Type and Number:
Japanese Patent JP6643239
Kind Code:
B2
Abstract:
Disclosed herein are nanoparticles containing MERS virus proteins in polymer structures, and compositions containing the nanoparticles formulated for administration as immunogenic compositions. Also provided herein are vector constructs encoding the proteins, and host cells containing the vector constructs. The disclosure also includes methods of making the nanoparticles and administering them to vertebrates, including methods of inducing immune responses to MERS that reduce or prevent infection by the virus.
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Inventors:
Smith, Gale
Riu, Ye
Masale, Michael
Riu, Ye
Masale, Michael
Application Number:
JP2016544012A
Publication Date:
February 12, 2020
Filing Date:
September 19, 2014
Export Citation:
Assignee:
Nova Bucks, Inc.
International Classes:
A61K39/215; A61K39/395; A61P31/14; C07K14/165; C07K16/08
Other References:
NOVAVAX,STIFEL 2013 HEALTHCARE CONFERENCE,[ONLINE],2013年 9月12日,URL,http://www.novavax.com/download/file/2013_09_12%20Novavax_Stifel_presentation.pdf
Novavax creates MERS-CoV vaccine candidate,Vaccine News daily,2013年 6月 7日,URL,https://vaccinenewsdaily.com/stories/510534663-novavax-creates-mers-cov-vaccine-candidate
DELMAS, B., et al.,J. Virology, 1990, Vol.64, No.11, pp.5367-5375
Vaccine, 2011, Vol.29, pp.6606-6613
J. Virology, 2013.08, Vol.87, No.21, pp.11950-11954
COTTEN, M. et al., 'S protein [Middle East respiratory syndrome coronavirus]' DATABASE NCBI Protein, [online], accession No.AGN70973, 10-Jun-2013, [retrieved on 2018.06.13],URL,https://www.ncbi.nlm.nih.gov/protein/511261317?sat=18&satkey=14547166
Novavax creates MERS-CoV vaccine candidate,Vaccine News daily,2013年 6月 7日,URL,https://vaccinenewsdaily.com/stories/510534663-novavax-creates-mers-cov-vaccine-candidate
DELMAS, B., et al.,J. Virology, 1990, Vol.64, No.11, pp.5367-5375
Vaccine, 2011, Vol.29, pp.6606-6613
J. Virology, 2013.08, Vol.87, No.21, pp.11950-11954
COTTEN, M. et al., 'S protein [Middle East respiratory syndrome coronavirus]' DATABASE NCBI Protein, [online], accession No.AGN70973, 10-Jun-2013, [retrieved on 2018.06.13],URL,https://www.ncbi.nlm.nih.gov/protein/511261317?sat=18&satkey=14547166
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito