Title:
眼の炎症状態を治療するためのエステル
Document Type and Number:
Japanese Patent JP6675361
Kind Code:
B2
Abstract:
The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a polyol wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. Anti-inflammatory lipid mediators can be selected from the group consisting of polyunsaturated fatty acids (e.g., omega-three and omega-six fatty acids), resolvins or a metabolically stable analog, protectins or a metabolically stable analog, lipoxins or a metabolically stable analog, prostaglandins or a metabolically stable analog, retinoic acids, endocannabinoids, metabolites thereof, and mixtures thereof. This composition can be topically delivered to the ocular surface via a preparation, solution, gel, ointment, and/or strip and/or a contact lens.
Inventors:
Galois-Berno Annabelle
MOLOCK, JR., Frank F.
Davis Carey El
Lorenz Cathy Osbourne
Young James Kay
Canavan Christie El
Le fan
MOLOCK, JR., Frank F.
Davis Carey El
Lorenz Cathy Osbourne
Young James Kay
Canavan Christie El
Le fan
Application Number:
JP2017195808A
Publication Date:
April 01, 2020
Filing Date:
October 06, 2017
Export Citation:
Assignee:
Johnson & Johnson Vision Care, Inc.
International Classes:
A61K31/232; A61K9/08; A61P27/02; A61P29/00
Domestic Patent References:
| JP2003514782A | ||||
| JP63246331A |
Foreign References:
| WO2010103404A1 | ||||
| US20020095000 | ||||
| WO2010106571A1 | ||||
| WO2004004738A1 | ||||
| US20050054723 |
Attorney, Agent or Firm:
Konobu Kato
Takafumi Oshima
Takafumi Oshima