Title:
幹細胞と膵島細胞を含む新膵島及びそれによる糖尿病の治療
Document Type and Number:
Japanese Patent JP6771567
Kind Code:
B2
Abstract:
Described are Neo-Islets comprising: a) dedifferentiated islet cells and mesenchymal and/or adipose stem cells; or b) redifferentiated islet cells and mesenchymal and/or adipose stem cells where the cells have been treated so as to facilitate redifferentiation. Further described herein are methods of generating Neo-Islets, the methods comprising: culturing a) dedifferentiated islet cells and mesenchymal and/or adipose stem cells; or b) redifferentiated islet cells and mesenchymal and/or adipose stem cells; on a surface that promotes the formation of cell clusters. Also described are methods of treating a subject, the methods comprising: providing to the subject Neo-Islets described herein. Additionally described are methods of treating a subject suffering from Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, and other types of insulin-dependent diabetes mellitus, or impaired glucose tolerance by providing to the subject Neo-Islet as described herein. Additionally described are methods of treatment in which intraperitoneal administration of islet-sized Neo-Islets composed of high numbers of mesenchymal stem cells and cultured islet cells, durably and reversibly treats, without hypoglycemia, both streptozotocin-induced and spontaneous Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, and other types of insulin-dependent diabetes mellitus, or impaired glucose tolerance.
Inventors:
Christoph Westenfelder
Ana gooch
Pin Jean
Juma H
Ana gooch
Pin Jean
Juma H
Application Number:
JP2018532519A
Publication Date:
October 21, 2020
Filing Date:
September 09, 2016
Export Citation:
Assignee:
Symbio Cell Tech LLC
International Classes:
A61K35/39; A61K9/06; A61K31/436; A61K35/28; A61P1/18; A61P3/10; A61P43/00
Domestic Patent References:
| JP2013507959A |
Foreign References:
| WO2015058139A1 |
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe