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Title:
GPR120アゴニストとしてのビアリール誘導体
Document Type and Number:
Japanese Patent JP6862033
Kind Code:
B2
Abstract:
The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

Inventors:
Yong Kwang Kim
Sang Yun Park
Hyun Woo Joe
Eun Sil Choi
Sun Yup Baek
Sun Wan Kang
Byung Kyu Kim
Jang Suk Yi
Sun Wook Kim
Saint-de-I
Application Number:
JP2019203369A
Publication Date:
April 21, 2021
Filing Date:
November 08, 2019
Export Citation:
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Assignee:
LG HAUSYS,LTD.
International Classes:
C07C229/42; A61K31/192; A61K31/196; A61K31/197; A61K31/341; A61K31/343; A61K31/353; A61K31/36; A61K31/381; A61K31/382; A61K31/397; A61K31/402; A61K31/404; A61K31/416; A61K31/4184; A61K31/42; A61K31/426; A61K31/427; A61K31/4418; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/444; A61K31/451; A61K31/4525; A61K31/4535; A61K31/454; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/496; A61K31/4965; A61K31/497; A61K31/505; A61K31/506; A61K31/517; A61K31/519; A61P1/16; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P13/12; A61P19/10; A61P25/00; A61P27/02; A61P29/00; C07C59/68; C07C59/72; C07C229/18; C07C317/22; C07C323/20; C07D209/08; C07D209/30; C07D211/34; C07D213/64; C07D213/68; C07D213/69; C07D213/70; C07D213/74; C07D231/56; C07D235/16; C07D239/34; C07D241/18; C07D261/08; C07D277/24; C07D277/34; C07D295/135; C07D307/42; C07D307/52; C07D307/79; C07D307/86; C07D307/94; C07D311/58; C07D317/46; C07D317/72; C07D333/16; C07D401/04; C07D401/10; C07D401/12; C07D401/14; C07D403/10; C07D405/04; C07D405/10; C07D405/12; C07D405/14; C07D407/04; C07D409/04; C07D409/10; C07D409/14; C07D413/10; C07D413/12; C07D417/10; C07D487/04
Domestic Patent References:
JP8501318A
JP2004500383A
JP2004505958A
JP2012510496A
JP2017531647A
Foreign References:
US20030134885
WO2002089738A1
WO2006038606A1
WO2014081756A1
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Attorney, Agent or Firm:
Shinya Mitsuhiro
Takashi Watanabe