Title:
腫瘍細胞を非腫瘍細胞に変換するための医薬的連合体及びその使用
Document Type and Number:
Japanese Patent JP6890836
Kind Code:
B2
Abstract:
The present disclosure provides a pharmaceutical association for use in the treatment, prevention and/or diagnostic of a neoplastic disease, said association comprising at least one growth factor receptor-binding compound, which activates at least one growth factor receptor of a neoplastic cell, and at least one bioactive carrier forming at least one covalent or non-covalent interaction with said at least one growth factor receptor-binding compound, and wherein said association reduces or suppresses, in the neoplastic cell, the gene expression of at least one cyclin D and/or reduces or suppresses the formation of at least one complex formed between said at least one cyclin D and at least one of cyclin dependent-kinase 4 or 6.
Inventors:
Zuani, Omar F.
Gocheva, Veronica
Gocheva, Veronica
Application Number:
JP2018514839A
Publication Date:
June 18, 2021
Filing Date:
September 15, 2016
Export Citation:
Assignee:
Histoid Akzien Gezel Shaft
International Classes:
A61K38/03; A61K38/08; A61K38/16; A61K38/18; A61K47/52; A61K47/56; A61K47/59; A61P35/00; A61P43/00; C12N5/09; C12Q1/02; G16B15/30
Domestic Patent References:
| JP2009502771A |
Foreign References:
| US20030185792 |
Attorney, Agent or Firm:
Atomi International Patent Office