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Document Type and Number:
Japanese Patent JPH0128744
Kind Code:
B2
Abstract:
The thioester of N-acetylcysteine with p-isobutylphenylpropionic acid simultaneously shows anti-inflammatory and mucolithic activities. It is prepared by reacting a reactive derivative of p-isobutylphenylpropionic acid and N-acetylcysteine at low temperature and in a polar solvent. The salts with organic and inorganic bases, with basic aminoacids and with basic antibiotics having macromolecular structure, are stable and generally water soluble, whereby the active principle of the invention can be formulated for oral, parenteral, rectal and topical administration.

Inventors:
ARUBERUTO RAINAA
Application Number:
JP18850981A
Publication Date:
June 05, 1989
Filing Date:
November 26, 1981
Export Citation:
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Assignee:
ZAMBON SPA
International Classes:
A61K31/20; A61K31/215; A61K31/265; A61P29/00; C07C67/00; C07C229/26; C07C239/00; C07C325/00; C07C327/34; C07H17/08



 
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