Document Type and Number:
Japanese Patent JPH0259145
Kind Code:
B2
Abstract:
Amidino compounds represented by the formula and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsin, antiplasmin, antikallikrein and antithrombin agents. Having strong anti-Cl activity and anti-complement activity, they are also useful as anti-complement agents. These amidino compounds are prepared by reacting carboxylic compounds represented by the formula R1-COOH or their reactive intermediates with amidinonaphthol represented by the formula and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof.
Inventors:
FUJII SETSUO
YAEGASHI TAKASHI
NAKAYAMA TOYOO
NUNOMURA SHIGEKI
SAKURAI YOJIRO
OKUTOME TOSHUKI
YAEGASHI TAKASHI
NAKAYAMA TOYOO
NUNOMURA SHIGEKI
SAKURAI YOJIRO
OKUTOME TOSHUKI
Application Number:
JP6494381A
Publication Date:
December 11, 1990
Filing Date:
April 28, 1981
Export Citation:
Assignee:
TORII YAKUHIN KK
International Classes:
A61K31/215; A61K31/155; A61K31/22; A61K31/23; A61K31/27; A61P1/00; A61P7/00; A61P13/02; A61P15/00; A61P37/00; A61P37/08; A61P43/00; C07C67/00; C07C69/035; C07C239/00; C07C257/18; C07C279/14; C11C3/04