Document Type and Number:
Japanese Patent JPH0347256
Kind Code:
B2
Abstract:
Novel alkane derivatives of the formula (I)
or a pharmaceutically acceptable salt thereof, wherein:
R1 is hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, or phenyl;
R2 is hydrogen, C1-C6 alkyl, or C2-C6 alkenyl;
R3 is hydrogen, C1-C10 alkyl, phenyl, C1-C10 alkyl-substituted phenyl, biphenyl, or benzylphenyl;
R4 is -COOR7, -CONR8R9 -CONHOH, -NR8R9, -SC(=NH)NH2, cyano, cyanothio,
where R7 is hydrogen or C1-C4 alkyl,
R8 and R9 are each independently hydrogen, C1-C3 alkyl, or when taken together with the nitrogen atom form a morpholine or N-methyl piperazine ring,
R is hydrogen, C1-C4 alkyl, or -CH2COOR7, and p is 0, 1, or 2;
R5 and R6 are each independently hydrogen or C1-C3 alkyl;
and n is 0-10 are leukotriene antagonists.
Inventors:
UINSUTON SUTANREI MAASHARU
JON HONFURETSUTO BAAJI
JON HONFURETSUTO BAAJI
Application Number:
JP20686683A
Publication Date:
July 18, 1991
Filing Date:
November 02, 1983
Export Citation:
Assignee:
LILLY CO ELI
International Classes:
C07C69/736; A61K31/16; A61K31/19; A61K31/215; A61K31/41; A61P11/00; C07C39/06; C07C45/71; C07C51/00; C07C59/125; C07C59/68; C07C59/74; C07C59/90; C07C67/00; C07C67/31; C07C69/712; C07C69/738; C07C213/00; C07C217/22; C07C217/48; C07C231/00; C07C231/02; C07C235/18; C07C235/20; C07C235/34; C07C239/00; C07C253/00; C07C255/13; C07C255/37; C07C259/06; C07C325/00; C07C331/10; C07C335/30; C07C335/32; C07D257/04; C07D295/02; C07D295/092
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