Title:
【発明の名称】新規抗微生物剤ジチオカルバモイルキノロン類
Document Type and Number:
Japanese Patent JPH03503533
Kind Code:
A
Abstract:
Antimicrobial dithiocarbamoyl quinolone compounds of the general formula: wherein (1) A<1>, A<2>, A<3>, R<1>, R<3>, R<4>, and R<6> form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and (2) (1) R<1> is X, R<3> is X, or both R<1> and R<3> are X; and (2) X is -R<1><5>-N(R<1><6>)(R<1><7>) or -R<1><5>-R<1><8>-N(R<1><9>)(R<1><7>), where (a) (1) R<1><5> is nil, alkyl, a carbocyclic ring, or a heterocyclic ring; and (2) R<1><6> is hydrogen; alkyl; alkenyl; a carbocyclic ring; a heterocyclic ring; or (3) when X is R<1><5>-N(R<1><6>)(R<1><7>), R<1><6> and R<1><5> may together comprise a heterocyclic ring including the nitrogen atom to which R<1><5> and R<1><6> are bonded; (b) R<1><7> is C(=S)-S-M, where M is a pharmaceutically-acceptable salt or biohydrolyzable ester; and (c) (1) R<1><8> is alkyl, a carbocyclic ring, or a heterocyclic ring; and (2) R<1><9> is hydrogen; alkyl; alkenyl; a carbocyclic ring; a heterocyclic ring; or (3) R<1><8> and R<1><9> may together comprise a heterocyclic ring including the nitrogen atom to which R<1><8> and R<1><9> are bonded; and pharmaceutically-acceptable salts and biohydrolyzable esters thereof, and hydrates thereof.
Inventors:
Dimas, Thomas Prosser, Junior
White, ronald eugene
White, ronald eugene
Application Number:
JP50063490A
Publication Date:
August 08, 1991
Filing Date:
October 24, 1989
Export Citation:
Assignee:
NORWICH EATON PHARMACEUTICALS, INC.
International Classes:
A61K31/435; A61K31/47; A61K31/535; A61P31/04; C07D215/56; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D417/14; C07D455/04; C07D463/00; C07D471/04; C07D477/10; C07D487/04; C07D498/04; C07D498/06; C07D499/00; C07D501/20; C07D503/00; C07D505/00; C07D513/04; C07D513/06; C07D519/00; (IPC1-7): A61K31/435; A61K31/47; A61K31/535; C07D215/56; C07D401/04; C07D403/04; C07D455/04; C07D471/04; C07D498/06; C07D513/04; C07D513/06; C07D519/00
Domestic Patent References:
| JPS62274855A | 1987-11-28 | |||
| JPS62274965A | 1987-11-28 | |||
| JPS57202170A | 1982-12-10 |
Attorney, Agent or Firm:
Kazuo Sato (2 outside)