Title:
【発明の名称】中枢神経系活性を有する複素環系アミン
Document Type and Number:
Japanese Patent JPH04506071
Kind Code:
A
Abstract:
Tricyclic nitrogen containing compounds, having central nervous system activity of structural formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and R3 are independently hydrogen, C1-6 alkyl, alkenyl, or alkynyl, C3-10 cycloalkyl, or R1 and R2 are joined to form a C3-7 cyclic amine which can contain additional heteroatoms; X is hydrogen, C1-6 alkyl, halogen, hydroxy, alkoxy, cyano, carboxamide, carboxyl, or carboalkoxyl; A is SO2, N, CH, CH2, CHCH3, C=O, C=S, C-SCH3, C=NH, C-NH2, C-NHCH3, C-NHCOOCH3, or C-NHCN; B is CH2, CH, C=O, N, NH or N-CH3; n is 0 or 1; and D is CH, CH2, C=O, O, N, NH or N-CH3. These new compounds are suitable for treating schizophrenia, Parkinson's disease, anxiety, depression or as compounds for lowering blood pressure in animal or human hosts.
Inventors:
Moon, Malcolm W
Hire, richard f
Morris, Janet Kay
Hire, richard f
Morris, Janet Kay
Application Number:
JP50848990A
Publication Date:
October 22, 1992
Filing Date:
May 15, 1990
Export Citation:
Assignee:
PHARMACIA&UPJOHN COMPANY
International Classes:
A61K31/00; A61K31/47; A61K31/473; A61K31/535; A61K31/54; A61P5/42; A61P9/12; A61P25/00; C07D221/06; A61P25/18; C07D215/40; C07D221/04; C07D455/04; C07D471/06; C07D498/06; C07D513/06; (IPC1-7): A61K31/47; A61K31/535; A61K31/54; C07D221/04; C07D455/04; C07D471/06; C07D498/06; C07D513/06
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)