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Document Type and Number:
Japanese Patent JPH05500801
Kind Code:
Pharmaceutical compositions containing a 57 amino acid protease inhibitor and uses for those compositions are taught. The protease inhibitor is referred to as A4i which is associated with Alzheimer's disease. In addition to the A4i protease, other analogs are taught as are pharmaceutical compositions containing such analogs and their uses in treating a variety of abnormalities associated with Kunitz-type basic protease inhibitors. For example, it has been found that pharmaceutical compositions containing A4i protease and analogs thereof inhibit plasmin and tryptase, and also inhibit pancreatic trypsin, alpha-chymotrypsin, tissue kallikrein and serum kallikrein. In that certain diseases are associated with a general release of proteases such as trypsin, chymotrypsin and elastase into the circulatory system pharmaceutical compositions containing A4i and analogs thereof can be used in the management of such diseases.

Cordell, Barbara
Schilling, James W.
Nobuhiko Katsunuma
Application Number:
Publication Date:
February 18, 1993
Filing Date:
June 04, 1990
Export Citation:
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International Classes:
C12N15/09; A61K38/55; A61K51/08; A61P7/02; A61P7/04; A61P17/02; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C07K14/005; C07K14/47; C07K14/81; C07K16/18; C07K16/38; C07K16/40; C07K19/00; C12N1/21; C12N5/00; C12N5/10; C12N9/99; C12N15/71; C12N15/863; C12P21/00; C12Q1/68; G01N33/68; A61K38/00; C12R1/19; C12R1/91; (IPC1-7): A61K37/64; C07K7/10; C07K99/00; C12N9/99
Domestic Patent References:
Attorney, Agent or Firm:
Shusaku Yamamoto

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