- Patent JPH0558629

Document Type and Number:

Japanese Patent JPH0558629

Kind Code:

B2

Abstract:

In the present invention an amide represented by the general formula: W - @ - B - Y is produced using a sulfonium salt represented by the general formula: as the starting material, to synthesizing a novel compound, i.e., an active ester represented by the general formula: and further reacting the active ester with a nucleophilic agent represented by the general formula: H-B-Y wherein R1 represents a hydrogen, an alkyl group or a halogen group; R2 and R3, which may be same or different, each represents an alkyl group; X<-> represents an anion typified by a halogen ion, a perchloric acid ion, a hydrogen sulfuric acid ion, a methylsulfuric acid ion, and a p-toluenesulfonic acid ion; W represents an alkyl group, alkoxy group in which R4 represents a halogen, a hydrogen or a methoxy or a C1 - C5 alkyl group substituted with 1 - 3 halogen atoms, an aryl group or a fluorenylmethoxy group, or represents, together with W- @-, an amino acid, a peptide, or a protein group, in which the terminal amino group and the side chain group of the amino acid has or has not a protective group, B represents a substituted or not-substituted imino group, Y represents an organic group or B and Y join together to represent a heterocyclic amine. Alternatively H-B-Y represents an amino acid in which a proper protective group is or is not introduced into alpha -carboxyl group and/or side chain, or a peptide or protein in which a proper protective group is or is not introduced into the terminal carboxyl group and/or side chain.

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Inventors:

TAKASHITA KATSUSHIGE

Application Number:

JP5585688A

Publication Date:

August 27, 1993

Filing Date:

March 08, 1988

Export Citation:

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Assignee:

SANSHIN KAGAKU KOGYO KK

International Classes:

C07C271/10; C07B31/00; C07B43/06; C07B51/00; C07C67/00; C07C231/02; C07C237/22; C07C239/00; C07C269/00; C07C325/00; C07C381/12; C07K1/06; C07K1/08; (IPC1-7): C07C381/12; C07B43/06; C07B51/00; C07C237/22; C07K1/06

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