Japanese Patent JPH0587500

B2

N-Benzyloxycarbonyl-L-aspartic acid (Z-Asp) is synthesized by adding benzyl chloroformate to a solution of L-aspartic acid and sodium hydroxide at temperatures from about 5 DEG -55 DEG C. and over a wide pH range of about 9.2 to 13.8 in the presence of a surfactant and/or a buffer and then acidifying the reaction mixture. Carrying out the reaction in the presence of a surfactant reduces cycle time, while maintaining a high yield with low by-product content. The buffer prevents wide fluctuations in pH and minimizes localized reaction. These conditions are desirable when the reaction rate has been increased by addition of a surfactant or an increase in temperature of the reaction mixture.

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KEI MINGU UAN
MEARII SHUIICHU CHEN
KUREI TSUUCHIMU CHEN

JP17688484A

December 16, 1993

August 27, 1984

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HATOKO CHEM CORP

C07C271/22; A23L27/30; C07C67/00; C07C239/00; C07K5/075; (IPC1-7): C07C271/22

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