Document Type and Number:
Japanese Patent JPH0587502
Kind Code:
B2
Abstract:
N-Benzyloxycarbonyl-L-aspartic acid (Z-Asp) is synthesized by adding benzyl chloroformate to a solution of L-aspartic acid and sodium hydroxide at relatively high temperatures of 35 DEG -55 DEG C. and over a wide pH range of 9.2-12.0 and acidifying the sodium salt product. The Z-Asp is prepared in high yields exceeding 90% and purity of better than 99% with only a minor amount of the by-product N-benzyloxycarbonyl aspartyl aspartic acid. The Z-Asp is suitable for conversion to aspartame. Carrying out the reaction at high temperatures significantly reduces cycle time while maintaining a high yield with a low dipeptide and unreacted L-aspartic acid content.
Inventors:
KEI MINGU UAN
MEARII SHUIICHU CHEN
ANRI DEII PENZE
MEARII SHUIICHU CHEN
ANRI DEII PENZE
Application Number:
JP17688684A
Publication Date:
December 16, 1993
Filing Date:
August 27, 1984
Export Citation:
Assignee:
HATOKO CHEM CORP
International Classes:
C07C271/22; A23L27/30; C07C67/00; C07C239/00; C07K5/075; (IPC1-7): C07C271/22
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