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Document Type and Number:
Japanese Patent JPH07504421
Kind Code:
Compounds are described of formula (I), wherein R<1> represents a hydroxyl group or a group selected from -OCOCH=CHCH(CH3)(CH2)3CH3, -OCOCH=CHC(CH3)=CHCH(CH3)CH2CH3 or -OCO-X-CH2CH(CH3)CH2CH3[where X is -CH=CHCH(CH3)-, -CH2CH(OH)CH(CH3)-, -CH=CHC(OH)(CH3)-, -CH2CH(OH)CH2- or -CH2CH2CH(CH3)-]; R<2> represents a hydroxyl group; R<3> represents a group selected from (a) (where R<8> is a hydrogen atom or an acetyl group), -C(CH3)=CHCH(CH2R<9>)CH2Ph where R<9> is a hydrogen or a hydroxyl group), -C(CH2OH)=CHCH(CH3)CH2Ph, -C(=CH2)CH(OH)CH(CH2OH)CH2Ph, -C(=CH2)CH(NHCOCH3)CH(CH3CH2Ph, -C(CH2NHCOCH3)=CHCH(CH3)CH2Ph and (b); R<4> and R<5> may each independently represent a hydrogen atom or a methyl group; R<6> and R<7> may each independently represent a hydrogen atom or a C1-4alkyl group; or R<6> represents a hydrogen atom and R<7> represents a group -C(=Y)NH2 where Y is an oxygen or sulphur atom or NH; and salts thereof. These compounds inhibit the enzyme squalene synthase and/or are intermediates for the preparation of compounds which inhibit the enzyme squalene synthase. Compounds of the invention may be formulated for use in a variety of conditions where a lowering of the level of blood plasma cholesterol in animals would be beneficial and for use in combating fungal infections in animals.

Application Number:
Publication Date:
May 18, 1995
Filing Date:
March 02, 1993
Export Citation:
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International Classes:
C07H9/02; A61K31/34; A61K31/70; A61K31/7028; A61P3/00; A61P3/06; A61P9/08; A61P9/10; A61P31/04; A61P43/00; C07D493/08; C07H9/04; C07H15/10; C07H19/01; (IPC1-7): C07D493/08; A61K31/34; A61K31/70; C07H9/02; C07H15/10

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